Tophi are little, chalk-coloured, stone-like deposits of uric acid that collect underneath the pores and skin and are most frequently found in skin across the joints and on the outside from the ear.
Jika anda sudah mempunyai bukti kerosakan akibat gout pada sinar-X sendi, atau anda mempunyai tophi, penyakit buah pinggang kronik atau batu karang, ubat-ubatan sebegini yang dapat membantu menurunkan kadar asid urik badan anda mungkin disyorkan. Pilihan yang ada termasuk:
Allopurinol adalah salah satu ubat utama dalam terapi penurunan urate (ULT), yang bertujuan untuk mengurangkan pengeluaran asid urik dalam badan. Di Malaysia, allopurinol biasanya dimulakan sekurang-kurangnya empat minggu selepas serangan gout akut untuk mengelakkan keadaan menjadi lebih teruk.
Kortikosteroid, sama ada diambil secara oral (melalui mulut) atau diberikan sebagai suntikan ke dalam sendi terjejas
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Baking soda mempu mengurangkan asid urik dalam badan dan mengurangkan keradangan akibat gout. Caranya:
Seterusnya, kortikosteroid biasanya digunakan hanya pada individu dengan keadaan gout yang tidak dapat mengambil NSAID atau colchicine sahaja. Kesan sampingan penggunaan kortikosteroid mungkin termasuk perubahan emosi, peningkatan kadar gula darah dan tekanan darah tinggi.
Probenecid might not perform very well in people who have kidney illness. As it might boost the threat of kidney stones, It's not advisable for people with a record of kidney stones. Feasible Negative effects incorporate headache, joint pain, loss of urge for food, and nausea.
Gout is usually a distressing arthritic situation that often begins in the massive toe and spreads to other joints, leaving them swollen and discolored. Therapy normally begins having an over-the-counter NSAID to simplicity soreness and inflammation.
Scientific tests in animals or human beings have shown fetal abnormalities and/or You can find constructive evidence of human fetal possibility depending on adverse response knowledge from investigational or advertising and marketing practical experience, and the threats associated with use in Expecting Ladies Obviously outweigh prospective benefits.
Ubat kortikosteroid seperti ubat prednison, dapat mengawal keradangan dan sakit gout. Kortikosteroid mungkin didapati dalam bentuk pil, atau boleh disuntik website ke sendi anda.
Incorporates a reduced prospective for abuse relative to People in agenda 3. It's a presently approved clinical use in treatment method in The usa. Abuse may well produce confined Actual physical dependence or psychological dependence relative to Individuals in timetable 3.
Urate-Decreasing Prescription drugs Urate-reducing medication are utilized to aid manage Serious gout and stop flares. They are encouraged for Individuals who have at the least two gout flares annually and those with troubles like tophi.
Relevant: Where to turn for suffering reduction - acetaminophen or NSAIDs? Uric acid-lowering medicines The ACR tips endorse managing gout with uric acid-decreasing medications for Individuals who have tophi (nodules that sort from a mass of uric acid crystals at joints or in tender tissues), radiographic evidence (X-ray or other imaging) of harm because of gout, kidney stones (individuals with gout have a heightened possibility of kidney stones as uric acid crystals can kind kidney stones in lots of people) or two or maybe more gout flares per year.